Salvia Divinorum 101: Use, Effects, History & Science

Salvia divinorum plant and a wooden statue

Salvia divinorum (salvia) a shrub native to Oaxaca, Mexico, which has been used spiritually and medicinally by indigenous Mazatec tribespeople for centuries. It’s a powerful natural hallucinogen that produces an intense psychedelic high. Today, it’s garnering attention in the West for recreational use, but also slowly for possible medical use.

The species S. divinorum is a member of the genus Salvia, a large group of more than 900 species belonging to the Lamiaceae (mint) family. Although the common name “sage” refers particularly to Salvia officinalis—from which the herb used in cooking is obtained—it may also refer to any ornamental or medicinal plant within the genus.

The salvia divinorum plant, hereafter referred to as salvia, is a tall shrub with square, hollow stems. It has hairless, ovate leaves, which may be dentate or toothed and are between ten and thirty centimetres in length. The plant grows to over a metre in height, and its stems are particularly prone to breaking and trailing along the ground, where they also enthusiastically form new root sites.

The flowers, which appear rarely, are white with purple calyxes, and seldom form viable seed. Instead, the plant’s propensity to form new roots sites along its stem allows for exceptional ease of vegetative propagation, which is the plant’s primary method of reproduction.

Where is salvia found?

Salvia grows in the cloud forests and tropical forests of the Sierra Mazateca, which is in the north-west of Oaxaca State in Mexico. Salvia is present at elevations of between 300 and 1,830 metres above sea level. It is commonly found growing along the edge of the frequent streams and rivers that run downhill to the Rio Tonto, a major tributary of the Rio Papaloapan.

Panoramic view of Sierra Mazateca forests

Salvia flourishes in moist, humid environments with low light conditions, and prefers black soils with high humus content. For many years, the Mazatec tribes concealed the locations that salvia is found in from European botanists and taxonomists due to the plant’s value and sacred status.

Cultivation of salvia seeds

Salvia presents somewhat of a conundrum to taxonomists, as it’s not fully understood whether the plant is a cultigen (a product of cultivation), a natural hybrid, or a true species. The uncertainty is due to the plant’s vegetative means of reproduction and unusual sterility, which is more common in sterile hybrids (mules and asses are examples of this phenomenon in mammals) or in inbred cultivars.

Recent genetic research has indicated that the plant is not an interspecific hybrid, although its origin remains obscure.

Salvia cuttings: An alternative to seeds

Due to the lack of viable seeds, salvia can only be cultivated by means of vegetative propagation (“cloning”). Cuttings are taken from a mature mother plant, and will form roots in tap water within two or three weeks. Flowering is photoperiod-dependent, just like cannabis, and occurs when day length drops to twelve hours or below.

What causes salvia’s psychoactive effects?

Salvia has been shown to contain the active ingredient salvinorin-A, a potent psychotropic molecule with the chemical formula C23H28O8. Unusually for a naturally-occurring hallucinogen, salvinorin-A does not contain a nitrogen atom and is therefore not an alkaloid (unlike DMT, mescaline and psilocybin).

In fact, it’s a terpenoid, the same class of organic chemical to which cannabinoids, menthol, camphor and many other important natural substances belong. By mass, it’s the most potent natural hallucinogen, being effective in doses as low as 200µg (psilocybin is effective at 6mg, DMT at 60mg, and mescaline at 100mg).

A person holding a salvia leaf

Salvinorin-A is a kappa-opioid receptor agonist, and is the first non-alkaloid known to affect this specific receptor. All other naturally-occurring hallucinogens affect the 5-HT2a serotonin receptor, but salvinorin-A has no effect on this receptor. It’s thought that salvinorin-A’s main effects are realised through agonising the kappa-opioid receptor. However, it’s now known that the substance is also a partial agonist of the D2 dopamine receptor.

Possible risks, and treatment of salvia intoxication

Due to the properties above, and unlike most other natural hallucinogens, salvinorin-A produces a dissociative state in the user that is often dysphoric. Intense feelings of well-being are not often reported; rather, the drug is reported to cause intense, and often harrowing and disturbing, visionary or trance-like states, although uncontrollable laughter is also commonly observed.

There are many potential side effects of using salvia, which mostly affect the brain (but there can also be physiological effects). These can include:

  • Brief, intense hallucinations
  • Paranoia
  • Mood changes
  • The feeling of being detached from one’s body
  • Altered visual perceptions
  • Slurred speech
  • Sweating
  • Dizziness

The high from using salvia is almost instant, and intense, although it’s short lived. As of now, there doesn’t seem to be a consensus on any type of treatment for salvia intoxication, though.

Traditional use of salvia

Salvia has been used by the indigenous Mazatec tribes in spiritual and religious ritual for hundreds of years. Typically, only the fresh leaf is used in Mazatec shamanic ritual. The leaf is crushed to extract the juices before being mixed with water and drunk, to produce the desired visionary effect. Alternatively, large quantities of fresh leaves may be chewed and swallowed.

Salvia divinorum purple flowers

Salvia is integral to the healing rituals practised by the Mazatec, as it allows the user to “access” the realm of the spirits that are believed to control sickness and health in the material world. Often, salvia is used as a substitute for psilocybin mushrooms, but there are some shamans who make primary use of salvia.

Usually, the salvia ritual takes place in darkness, and participants are encouraged to lie in silence and stillness. Before the leaves or infused water is consumed, it’s blessed and consecrated to the spirits. Then, the shaman (and possibly the sick individual or individuals too) consume the salvia and wait for the effects to manifest. If the visions are meaningful to the shaman, the cause of the illness is identified, and a course of action can be chosen.

Salvia was also historically used to directly treat several illnesses including headaches, rheumatism, diarrhoea and anaemia; for these purposes, it’s used at lower doses and is commonly administered as a tea.

Current use and availability

Now, salvia and salvia extracts are abundant and easy to source, either online or from local smart shops and head shops. It’s common to find products on sale which consist of dried leaves fortified with extracted juices to increase their potency—such products are often sold in strength classes of 10x, 20x, and even higher (although there is no standard of potency and variability between products is high).

Ground dried salvia leaves and a plastic meter beside

While salvia is used recreationally by most users, ritualistic use persists within the remaining Mazatec tribes; through syncretism of traditional religion and Christian beliefs imported by the Spanish conquistadors, the plant is now known as ska María Pastora (“leaves of the shepherdess Mary”) and is associated with the Virgin Mary.

Legality of salvia – seeds and plant

Salvia is legal in most countries and in most U.S. states. However, there are some that consider its hallucinogenic effects to be dangerous and societally unacceptable, and have therefore banned or are attempting to ban the plant.

At least thirteen countries have banned or controlled salvia in some way, including Australia, Belgium, Croatia, Germany, Italy, Canada, Denmark and Finland. Some countries have made it entirely illegal, while in other places, there are simply restrictions (For example: No import or sales, but personal cultivation, possession, or consumption is decriminalized).

In the U.S. the Schedule of Controlled Substances doesn’t list salvia as a controlled substance, although various states including Oklahoma, New Mexico, Michigan, and Florida (where possession can lead to up to five years’ imprisonment) have enacted their own legislation.

Why plants like salvia must be protected

As with most attempts to prohibit a substance, such actions are more likely to end in a black-market existing for a previously taxable item. This likely will result in an increase in criminality and price (and decrease in quality) that usually accompanies such policies, rather than the substance in question simply fading out of popular use.

  • Disclaimer:
    This article is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with your doctor or other licensed medical professional. Do not delay seeking medical advice or disregard medical advice due to something you have read on this website.


18 thoughts on “Salvia Divinorum 101: Use, Effects, History & Science”

  1. My experience with smoking Salvia was very interesting. I have used this sacred plant on 3 occasions. Each time I met “little people”. My involvement with them was intense and good. The visuals was very bizarre. I entered a 2 dimensional reality, which was a little uncomfortable. My best time was the last time when a couple of these little spirit people sat with me and shared with me their information about the nature of consciousness. I highly respect all medicine plants and the spirits of these plants. And for that respect I feel they treat me kindly and are generous with me.

  2. when i found out about this some 20 yrs ago. i was single, and i’d experiment with large dosages while video was running to see what i was doing while in the stream. i’d start at the computer desk. and as it was taking effect, i immediately would transfer to the outside, in the back yard yet it was like in an alley. and “always” the motion was going from right to left, with a purpose of unity. family was like the central theme. and although i could remember it during the movements, when done or semi conscious i couldn’t quite put my finger on where i’d just been. but it left me with interest to keep the episodes going. i did, and it was always the same level. and although it felt harsh on the body, i was eager to document the next one. the levels were spot on. i never got to level 5.

    1. Mark Smith - Sensi Seeds

      Good morning Buck,

      I hope you;re having an excellent day,
      Thank you for sharing your experiences with Salvia Divinorum with us 🙂
      Keep us posted if you ever reach level 5!

      Thanks again and I hope you continue to enjoy the blog!


  3. Mommabear66

    If these plants are illegal in some states, why can we buy the plants at local stores? I have several salvia plants. Ive harvested the seeds to grow more plants. I tossed a bunch of seeds last fall and this spring, they are popping up everywhere. I myself wouldn’t try smoking it, due to being a chicken lol. I guess I’m wondering why seeds are so rare and why people can’t buy them.

    1. Mark - Sensi Seeds

      Good afternoon,

      Thanks for your comment,

      In the United States, Salvia is not regulated under the Controlled Substances Act. However, some states has passed their own laws regarding the consummation and cultivation, as Salvinorin A and Salvia divinorum are often abused for their hallucinogenic properties.

      The species S. divinorum is a member of the genus Salvia, a large group of more than 900 species belonging to the Lamiaceae (mint) family. Other members of the Salvia genus do not contain Salvinorin A and are therefore not psychoactive. Many of the same species are available to buy in local garden centres.

      Due to the lack of viable seeds, salvia can only be cultivated by means of vegetative propagation (“cloning”). Cuttings are taken from a mature mother plant, and will form roots in tap water within two or three weeks.

      This article on Hawaiian Baby Woodrose Plant – What Is It and What Is It Used For? may also be of interest to you.

      Thanks again, and have a great day!


  4. Hello there. Are you sending salvia divinorum seeds? Are you sending plants to raise me?

    1. Scarlet Palmer - Sensi Seeds

      Hi there,

      We don’t sell salvia divinorum seeds, I’m afraid. They are very hard to obtain so if you want to grow it, your best chance would be to find someone with a plant who will let you have a cutting from it.

      With best wishes,


    1. Scarlet Palmer - Sensi Seeds

      Hi Ramtin,

      Thank you for your comment. I’m afraid I can’t insert pictures here but if you search ‘saliva divinorum seeds’or ‘The Salvia divinorum Research and Information Center’ you should be able to find some.

      With best wishes,


      1. dear scarlet thank you very much for answer my question .I live in iran . someone say me this plant have seed for cultivate . i tried search internet and plant book but don’t seen stable picture form seed of salvia divinorum . please if you seen seed picture link to me thank you

    2. Connie Wagar

      I who do not believe in drugs ..tried this a few years ago. The amusement was my son feared I would panic..but saw my reaction and sat watching for afew , All he saw was me telling what I saw and giggling. As a river of flowers began in the corner of a room flowing past me and the fireplace. And then the flowers began to be replaced by the Teddy a river of bears… Then I looked at the couch. The colors began to melt and flow like a waterfall of color…and whoosh it was over. No hungry, no feeling strange nothing. It was interesting.

  5. im really interested in buying seeds. Would you know where i can get them iv been looking every where!!..

    1. Did you even read the article? It says “Due to the lack of viable seeds, salvia can only be cultivated by means of vegetative propagation (“cloning”).”

      The term “lack of viable seeds” means that THERE ARE NO SEEDS FOR THIS PLANT!


        This is false. Don’t be uninformed. Read a book and/or do your own research.

      2. well there are seeds for this plant even though extremely rare! and anyway, you are so rude, you should probably take ayahuasca if not salvia

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