by Seshata on 12/06/2017 | Medicinal

Cannabinoid Science 101: What is Cannabidivarin (CBDV)?

Cannabidivarin Cannabidivarin (CBDV) is a naturally-occurring phytocannabinoid that occurs in small traces in certain strains of the cannabis plant. Although less studied than its more famous counterparts such as THC and CBD, research is beginning to uncover the medical potential of CBDV to treat epilepsy and other neurological conditions.


Structure and Properties of the CBDV Molecule

CBDV is to CBD what THCV is to THC. Both CBDV and THCV are known as propyl cannabinoids, and they contain a propyl chain instead of a pentyl chain within the molecule. This subtle but important difference means that the propyl molecules can have very different properties to their pentane “parents”.

Although THC and THCV have almost opposite effects to each other, CBD and its propyl counterpart CBDV appear to have broadly similar applications in medicine. CBDV is non-psychoactive, and like CBD, it appears to have strong effectiveness as an anticonvulsant and antiepileptic.

 

Cannabinoid Science 101: What is Cannabidivarin (CBDV)? - Sensi Seeds Blog
CBDV is more common in feral and landrace cannabis from northern India (© Wiki Commons)

CBDV in the Cannabis Plant

CBDV has been found in high concentrations in feral or landrace “indica” populations found in northwest India, and in hashish from Pakistan. It is also present in many Mexican populations of cannabis, although in much smaller quantities. Generally, CBDV is found in plants that are higher in CBD and lower in THC.

CBD and THC are known to form via a reaction between cannabigerolic acid (CBGA) and CBD synthase or THC synthase respectively. THCV is known to form via a reaction with cannabigerovarin acid (CBGVA) and THCV synthase, so presumably a similar mechanism exists for CBDV, but this has apparently not been elucidated.

Medical Potential of CBDV

CBDV-rich botanical extracts have been shown to possess strongly anticonvulsant properties in mice and rats, as well as actually suppressing the expression of certain genes related to epilepsy.

Much of the existing research on CBDV has been conducted by GW Pharmaceuticals and Otsuka Pharmaceuticals, who have filed a joint patent on a whole-plant extract rich in CBDV and CBD, which also contains CBC and CBCV. This extract is intended to treat neurological conditions including epilepsy.

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Beth ulanowski

I have progressing alzheimers I am 67 and was diagnosed 4 years ago. I am in Pennsylvania and New Jersey, any help with getting marijuana in either or both of these states

25/06/2017

Scarlet Palmer

Dear Beth,

Thank you for your comment. We are sorry to hear about your situation. Unfortunately, as Sensi Seeds is not a medical practice, we are not able to provide any advice relating to medical situations other than to consult your doctor or other licensed medical professional. This article, written specifically for healthcare providers who may not be aware of the many properties of cannabis, may be useful to you in talking with your doctor. You could also try to contact local medicinal cannabis support groups, if you have not already done so. In the UK, there is the United Patients Alliance (you can find them on Facebook) and in the US and EU there are many branches of NORML (google NORML followed by your area name). We hope this is helpful.

With best wishes,

Scarlet

28/06/2017

Boris Banas

There is a mistake:
"they contain a propyl chain instead of a pentane ring within the molecule" should be replaced by:
"they contain a propyl chain instead of a pentyl chain within the molecule."
Please correct this.

07/07/2017

Scarlet Palmer

Hi Boris,

Thank you for pointing this out. I have passed your comment on to the author of this article. We hope you continue to enjoy the blog!

With best wishes,

Scarlet

11/07/2017

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