by Seshata on 26/12/2014 | Medicinal

Top 4 benefits of cannabis for Crohn’s disease

Crohn’s disease is a type of inflammatory bowel disease that is believed to be caused by a combination of bacterial, immunological and environmental factors. The disease is progressive and incurable, and causes a range of severe and debilitating symptoms. Substantial evidence indicates that cannabis can help to manage symptoms.


Anti-inflammatory

Inflammatory processes are the primary mechanism of Crohn’s disease. The disease may affect any part of the gastrointestinal (GI) tract from the mouth to the anus, but the most commonly affected areas are the colon and the ileum (the large and small intestine), particularly the terminal section of the ileum that connects to the colon. Patches of chronic inflammation can lead to diarrhoea, bleeding and tearing of the GI tract lining, and bowel obstructions. In severe cases, portions of the intestine may need to be removed entirely.

Cannabis is used as a means of self-medication by a significant proportion of Crohn’s sufferers, and is anecdotally reported to provide substantial subjective improvements to the majority of symptoms, including inflammatory pain. Inflammation is well-known to be regulated by the endocannabinoid system, which—as the gut contains very high levels of cannabinoid receptors—has a fundamental role to play in inflammatory diseases of the GI tract.

In various studies, use of exogenous cannabinoids including ??-THC and CBD has been shown to activate the cannabinoid receptors of the GI tract and assist in the reduction of chronic inflammation. Both CB1- and CB2-receptors are present in the GI tract; the latter are usually less common than the former, but are present in far greater concentrations in individuals suffering from inflammatory bowel disease. It has been postulated that the CB2-receptors have an important role to play in modulating inflammatory pain, particularly that originating in the gut.

Antidiarrhoeal

Crohn's 2
Diarrhoea, cramping and abdominal pain are common symptoms of Crohn’s (© Evil Erin)

Diarrhoea is the most common primary symptom of Crohn’s disease. Depending on what part of the GI tract is affected, the stool may be mixed with mucus, pus or blood, and may be more or less watery. A sensation of urgency to defecate is common, along with a sensation of incomplete evacuation (known as tenesmus).

Cannabis has been used to treat diarrhoea for millennia, and modern research has provided empirical evidence of its efficacy. Crohn’s sufferers are thought to experience diarrhoea due to inflammation of the intestinal mucosa (the mucous membrane that lines the GI tract), as well as increased fluid secretion, reduced ability to absorb fluid, and presence of bacterial agents. Cannabis may ease symptoms of diarrhoea in Crohn’s due to its antibacterial properties, as well as its anti-inflammatory effects.

Activation of the CB1-receptors in the GI tract may also play an important role in improving symptoms of diarrhoea by reducing intestinal motility and fluid secretion; it is believed that this occurs through inhibition of acetylcholine released from the enteric nerves (i.e. those found in the peripheral nervous system, which helps regulate the GI tract). Acetylcholine, a neurotransmitter with a wide range of important functions, is well-known to increase peristalsis (gut motility).

Analgesic

Up to 70% of Crohn’s sufferers suffer from chronic pain. In the early stages of terminal ileitis (the form of Crohn’s that affects the terminal ileum), pain in the lower right side of the abdomen is common, and is often mistaken for appendicitis. Pain is generally a result of chronic inflammation, but may be a result of tearing or denudation of the intestinal lining, abdominal distention or bowel obstructions.

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Crohn’s is also capable of causing severe pain to the sufferer (© A30_Tsitika)

Cannabis may help improve symptoms of pain in Crohn’s sufferers by directly acting to reduce inflammation, by reducing the severity of abdominal distention, and by easing the symptoms of diarrhoea through reduction of gut spasms and inhibition of fluid release.

Although no formal studies into the effects of cannabis use on Crohn’s-related pain have been conducted thus far, there have been several questionnaires and surveys of patients, who have reported significant improvements in management of chronic pain. A pilot study conducted in California in 2005 questioned 12 Crohn’s sufferers on their perception of various major symptoms before and after commencing use of cannabis. Cannabis use was reported to improve all evaluated signs and symptoms, including pain—which was reported to rank up to 6.5 out of 10 on a subjective scale of severity prior to cannabis use, and just 2 out of 10 subsequent to cannabis use.

Appetite stimulant (orexigenic)

The aforementioned pilot study also found that patients reported a marked improvement in appetite when using cannabis, from approximately 1 out of 10 to almost 7 out of 10 on the scale. Appetite loss is a common symptom of Crohn’s, and often occurs as a result of chronic nausea and abdominal pain. Severe appetite loss can lead to dramatic unintentional weight loss in particularly bad flare-ups. As well as improving appetite, cannabis use led to less frequent defecation due to its influence on gut motility; these two factors combined caused the majority of patients to achieve weight gain after commencing use of cannabis.

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Severe appetite loss, nausea and weight loss are common in Crohn’s patients (© S)

Cannabis use can increase appetite in Crohn’s sufferers by reducing abdominal pain and inhibiting excessive peristalsis; however, it also helps to increase sensations of hunger by directly agonizing certain receptors in the GI tract that usually respond to the presence of ghrelin (an important ‘hunger hormone’ that has also shown signs of being a useful treatment for Crohn’s).

Various studies have shown that presence of ghrelin or cannabinoid agonists such as THC cause increased production of an enzyme—AMP-activated protein kinase (AMPK)—in the hypothalamus. The enzyme is crucial to the metabolic processes that regulate energy homeostasis (energy balance) in the body, and is produced in response to stimulation of the GHS-R1a ghrelin receptors found in the GI tract. Thus, THC can effectively do the job of ghrelin by activating the receptors and directly stimulating the brain to produce sensations of hunger.

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Adrian Kolodziej

Interesujacy material. Dziekuje za to Tobie! Zachecam innych do zapoznania sie z trescia artykulu. Mam pytanie i prosze o Twój kontakt na maila.

23/01/2015

David Cannafacts

Thank you for the comment Adrian. If you wish to contact us, feel free to do so by email at info@sensiseeds.com.
Take care

23/01/2015

David James smith

Best medicine EVER!

18/04/2015

John Collins

I was diagnosed with crohns disease in February 2015 after months of intense abdominal pain and severe nausea. It inflamed so much that i had to have a large section of my colon removed. Cannabis is not yet legal for treatment in Florida yet but i would like to try this. The Dr.s want me on antibiotics and immune system suppres

06/05/2015

john

John collins.

Try cdb oil. It's legal in florida and has worked for me.

23/05/2015

Shawn Mcintyre

I was diagnosed with Crohns back in 86 and have had numerous surgeries for it. I have also been on all of the treatments for it and have failed of of all of them. I have asked my doctor about mmj for my crohns but get the usual run around. Dam near impossible to find a doc that will prescribe it for me even though it's allowed up here in Canada. The doctors would rather push the opiates.

03/06/2015

herman

hoe do you dose it? I m a M D, we hace just release medical use of marihuana. I Wonder how to indicate, like pills.. how much miligram in oil? or something like that. thanks

23/06/2015

James

Hi Seshata

I have Crohn's pretty bad and have had surgery in the past. I looking for a type of marijuana seed to grow my own plants in helping to fight Crohn's. If you have other advice for me feel free to pass it my direction. Thank you in advance for your help. Jim

12/07/2015

Kenneth Parker

I have had crohn's for 45 years
tried remincade bad side affect
I'm on humira 40mg pen every week
This info was great!!!!
Thanks

09/09/2015

Kenneth Parker

I have had a colon resection 42 years ago
Things are always up the down

09/09/2015

Mmj cohn pat

To the M.D. 7mg per 50 pounds per sitting up to not pass 3 sittings a day is how i was told to use it.

13/10/2015

Sara

My son, 3.5, has been taking cbd for a little over a month for his Crohn's. It's really helping! We noticed a significant improvement within two weeks and he has been going steady for most of that time. Had a minor flare over Christmas, but I think we are back on track now.
-Sara

18/05/2017

Jenna

According to this page, which cites a study, cannabis has only a covering effect for Crohn's and can cause problems outside of helping symptoms.

https://www.emaxhealth.com/1020/what-effect-does-smoking-marijiuana-have-crohns-disease

27/06/2017

online420card

Cannabis certainly has a lot of medical benefits and can provide relief for gastrointestinal disorders. The available clinical evidence and anecdotal reports are fascinating and hopefully, we will continue to hear more success stories of patients on their path to recovery.

04/12/2017

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