by Miranda on 20/04/2015 | Medicinal

Cannabis and Endometriosis, the silent disease

Endometriosis The International Week of Endometriosis is held in March each year, and this year was no exception. This article addresses this largely unknown disease only suffered by women, and analyses the main potential benefits of the therapeutic use of cannabis for its treatment.


It may be known as the silent disease, but the number of women who suffer endometriosis has now reached 176 million around the world. Their lives are bound by the disease, and the suffering and misunderstanding that stems from the ignorance and silence surrounding it. More chronic and disabling than most, the disease has devastating consequences for feminine fertility.

Rectifying the scarcity of medical knowledge and the lack of financial resources dedicated to researching the causes and treatments has not been made a priority. As a result, countless women have had to consult several specialists, or have operations, before receiving a diagnosis, even though the number of women affected grows considerably every year.

More chronic and disabling than most, the disease has devastating consequences for feminine fertility. (©Danni Suplicki)
More chronic and disabling than most, the disease has devastating consequences for feminine fertility. (©Danni Suplicki)

What is Endometriosis?

Endometriosis is a disorder whereby the endometrial tissue, the tissue women shed each month during menstruation, spreads to around the ovaries in the majority of cases, but sometimes also to other parts of the body, such as the peritoneum, the intestine and other parts of the abdominal cavity, forming what are called endometriomas or endometriotic cysts. In some cases, the endometrial tissue even reaches the lungs.

Model of endometriosis development (©Mitopencourseware)
Model of endometriosis development (©Mitopencourseware)

Symptoms

The disease is particularly characterized by severe pain, alongside irregular bleeding and fertility problems. The pain that occurs during periods, also known as dysmenorrhea, is normally a physiological pain caused by the inflammatory alterations suffered by women during menstruation. In the case of endometriosis, however, painful periods are also manifested at other times: abdominal pain and cramps before and during menstruation, pain during or after sexual intercourse, painful bowel movements, and pelvic or lower back pain. Besides all this unbearable pain, many of these women also experience vomiting, fainting and extreme irritability.

Many specialists believe that the normal menstrual cycle should not be painful, and that the premenstrual cycle should not occur, as the presence of both of them indicates a neuroendocrine alteration in the body.

The disease is particularly characterized by severe pain. (©alterna)
The disease is particularly characterized by severe pain. (©alterna)

Diagnosis

Despite the fact that the average time taken to diagnose endometriosis is around 7-8 years, some women have had to wait almost 30. Although endometriosis usually begins to appear when regular menstruation begins – that is to say, in adolescence – patients suffer irremediably until doctors can give them the correct diagnosis. They continue suffering afterwards too, as explained by the patients themselves in this revealing and extremely interesting documentary, Endometriosis, the tip of the iceberg, filmed by RTVE in 2010.

Sometimes the average number of specialists which a patient must consult before being diagnosed is 5 to 6; sometimes even more. It is estimated that 40% of women who have difficulty getting pregnant, and between 8 and 10% of women of childbearing age, suffer from the disease. It is currently the most serious pathology in gynaecology and the number of affected women has increased enormously in recent years.

Most common treatments

The type of treatment depends on the age, the severity of the symptoms, the severity of the disease, and whether the woman wishes to have children in the future. Depending on each of these aspects, there are various treatment options.

Given that one of the main symptoms of endometriosis is pain, one of the basic treatments is soothing this symptom with analgesics, whether over-the-counter, like paracetamol and ibuprofen, or prescription drugs, if the pain is stronger. Also, patients are advised to do exercise, use relaxation techniques, and have regular medical check-ups to make sure the disease does not worsen.

If the symptoms are minor, hormone therapies are also used to prevent endometriosis from worsening, but they clearly do not cure it. Contraceptive pills usually ease most symptoms, but they do not prevent scarring nor do they heal any damage already done. Progesterone pills or injections and gonadotropin-releasing hormone agonists help to reduce the size of tumours and prevent the ovaries from producing oestrogen, respectively, but they also have serious side effects.

The most frequent treatment, when the symptoms are serious and do not remit with other treatments, is surgery. Normally, it is performed using laparoscopy, which helps to diagnose the disease once and for all, and can also eliminate tumours or cysts and scar or endometrial tissue. Other techniques used are laparotomy and hysterectomy, with the latter being the most aggressive surgery of all and normally a last-resort solution.

Common locations of endometriosis implants (©iwannagetpregnant9)
Common locations of endometriosis implants (©iwannagetpregnant9)

The problem is that during most of these surgical interventions, surgeons do not completely remove the endometrial tissue and the cells left behind reproduce immediately, forming a sheet of tissue as hard as marble. In addition, the disease usually relapses. It is thus vital that all the nodules of endometriosis are removed during a single instance of optimal surgery. It also seems evident that there should be consensus in the medical community in regard to the treatment of endometriosis, and that new less aggressive treatments must be found. The multiple benefits provided by cannabis could clearly be applied in this regard.

What causes endometriosis?

There are different theories on the cause of endometriosis. Specialists point to intrinsic genetic and personal factors, although they do not rule out possible environmental factors as triggers of this aggressive ailment.

According to Dr Carme Valls Llobet, endocrinology doctor and director of the Women and Health Program (CAPS), it would seem that the endometrium of affected patients has some molecular immunohistochemical characteristics that give these molecules the ability to adhere to the surface of the peritoneum, multiply, and increase the vascularization around the implants. These immunological alterations may also be due to environmental factors. In endometriosis, the tissue that enters the abdominal cavity generates new tissue through angiogenesis. The reason for this major inner proliferation is the presence of a hormone which greatly stimulates it: oestrogen. Oestrogens are, however, also found in the environment, where there are over 15,000 substances of this type: in water (bisphenols), in the air (hydrocarbons which are released in car exhaust during combustion), and in foods (dioxins in animal feed).

Estrogenic compounds. Polyhalogenated aromatic compounds (dioxin and dioxin-like) (©Mitopencourseware)
Estrogenic compounds. Polyhalogenated aromatic compounds (dioxin and dioxin-like) (©Mitopencourseware)

Research carried out by the Endometriosis Association at the beginning of the 1990s, discovered an initial link between exposure to dioxin (TCCD) and the development of endometriosis. Dioxin is a toxic chemical substance derived from the manufacture of pesticides, pulp and paper bleaching, and medical and municipal waste incineration. A study conducted by the EA discovered that a colony of chimpanzees had developed endometriosis after being exposed to dioxin. Of the chimpanzees exposed, 79% developed endometriosis, and furthermore, the higher the exposure to dioxin, the more severe the endometriosis.

How do cannabis and cannabinoids help in the treatment of endometriosis?

As we have explained, endometriosis is a chronic disease and there is still no cure. We have extensive medical and scientific evidence that demonstrates that the cannabinoids contained in the cannabis plant (phytocannabinoids) can ease the majority of the symptoms caused by endometriosis, such as pain, depression, headache, hypoglycemia, anxiety, fatigue, inflammation, and many others.

Anti-inflammatory and immunoregulatory properties

Many patients say they have benefited from consuming cannabis during the crises of certain inflammatory diseases, especially if they have an autoimmune component. In these cases, it seems that cannabis not only acts as an analgesic, but also has an anti-inflammatory action. This has been demonstrated in several studies with experiments on animals.

It is believed that antagonists, like CBD, and agonists, such as THC and the endogenous agonist 2-AG, reduce inflammation by inhibiting the function of macrophages, which are large, specialized white blood cells that are essential for various immune responses.

Sensi Seeds CBD Oil
Sensi Seeds CBD oil

Research indicates that cannabidiol (CBD), the non-psychoactive component of cannabis, is responsible for the reduction of inflammation associated with chronic inflammatory states, as demonstrated in a 2004 study by Italian researchers from the University of Milano-Bicocca. In the case of endometriosis, the cells that line the uterus (the endometrium) are present outside of it and can bleed, releasing inflammatory mediators and causing localised pain. The administration of cannabidiol greatly improves the patients’ quality of life because they can control the pain, and even completely stop taking any other medicine.

Analgesic properties

Cannabis is widely used in the treatment of chronic pain resulting from a large number of different diseases. Perhaps it is the therapeutic application of marijuana that has been referred to most throughout the centuries, from its appearance in the first pharmacopeia of the emperor Shen Nung (3750 B.C.) to Queen Victoria’s reference to its use in the nineteenth century. A tincture of cannabis was prescribed by her personal physician for the menstrual pain and cramps (dysmenorrhea) that she experienced. In that century and before the commercialisation of opium, it was considered one of the most valuable medicines.

Cannabis is widely used in the treatment of chronic pain resulting from a large number of different diseases. (©Steven Schwartz)
Cannabis is widely used in the treatment of chronic pain resulting from a large number of different diseases. (©Steven Schwartz)

Researchers from Florida State University in Tallahassee (U.S.A.) have studied the role of the endocannabinoid system in endometriosis-associated pain. Using a rat model, they discovered that the agonists of the CB1 receptors reduce endometriosis-associated hyperalgesia, whereas the antagonists of these receptors increase it. Blocking the CB1 receptors increased the sensitivity to pain, while stimulating them reduced it. The authors of this study concluded that the endocannabinoid system plays an important role in the development of abnormal growths and pain associated with endometriosis, which suggests that cannabinoids could provide “a novel approach for the development of badly-needed new treatments for endometriosis pain.”

Control cell growth

Cannabinoids also have properties that can be used to control another main aspect of severe endometriosis: hyperproliferation. Due to their effect on proliferation, apoptosis and angiogenesis, cannabinoids control cell growth and regulate cell migration. Its anti-proliferative effects are the result of the inhibition of growth factors and the deregulation of signalling pathways. These mechanisms have suggested new goals in the treatment of endometriosis, as endometrial cells have a hyperproliferative phenotype and pro-angiogenic properties.

Cannabigerol, one of the cannabinoids of cannabis (©MarihuanayMedicina)
Cannabigerol, one of the cannabinoids of cannabis (©MarihuanayMedicina)

Researchers of various institutions in Paris conducted a study in 2010 in which they demonstrated that cannabinoids reduce the growth of human endometrial tissue implanted in mice, and came to the conclusion that cannabinoid agonists exert anti-proliferative effects on stromal endometriotic cells.

Endometriosis and the endocannabinoid system (ECS)

Endocannabinoids are natural endogenous cannabinoids produced by the human body that enable various biological functions and activate cannabinoid receptors (CB1 and CB2). Due to the importance of the endocannabinoid system, drugs that can interfere in the activity of endocannabinoids are currently considered candidates for the treatment of various diseases, including endometriosis.

Many of the components of the endocannabinoid system are found in the endometrial tissue and their levels are regulated by the menstrual cycle, as has been proven in rodent models with the disease. Among these components are type 1 and type 2 cannabinoid receptors (CB1 and CB2), N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD), an enzyme which synthesizes endocannabinoids, and fatty acid amide hydrolase (FAAH), an enzyme that breaks down endocannabinoids. The highest concentration of anandamide endocannabinoid (AEA) in the reproductive system is found in the uterus.

A recent study, which we have not mentioned previously and which used a rat model, discovered that CB1 cannabinoid receptors are expressed in the somata as well as in the fibres of sensory and sympathetic neurons which innervate the abnormal growth of endometriosis. It was determined that CB1 receptor agonists reduce hyperalgesia associated with endometriosis, whereas CB1 receptor antagonists increase it. Together these discoveries suggest that the endocannabinoid system contributes to the mechanisms which underlie the peripheral innervation of abnormal growths and endometriosis-associated pain, thus providing a novel approach for the development of badly needed new treatments.

It is thus clear that endometriosis is associated with clinical endocannabinoid deficiency (CECD). Women with endometriosis have lower levels of CB1 receptors in the endometrial tissue. The reduction of the ECS function leads to the growth of the endometriosis throughout the body and to feeling more pain. Endometriotic pain is mediated with the CB1 receptor.

It has been demonstrated that human endometrial cells proliferated (divided and grew) less when they were stimulated with a synthetic cannabinoid called WIN 55212-2. Studies on endometriosis conducted on rodents have discovered that animals had more pain when they were treated with AM251, a drug which inhibits the cannabinoid receptors, and less pain when they were treated with WIN 55212-2.

Likewise, environmental toxins like dioxin have been linked to endocannabinoid deficiency and endometriosis. Dioxin reduces the levels of CB1 in the endometrial tissue. As we are subjected to contamination in the air, in water, and in food, it is not surprising that so many women in developed countries now have severe endometriosis. It is very probable that in the future more toxins will be associated with the risk of endometriosis, as well as with endocannabinoid deficiency.

Continued research is necessary

It is essential to research in greater depth the levels of endocannabinoids in women in order to determine whether they are lower in the plasma or in the endometrial cells of women with endometriosis, or whether the levels of endocannabinoids change throughout the menstrual cycle in human beings, as occurs in rodents. We can thus precisely determine if women who use therapies with cannabinoids experience less pain and a reduction in endometrial growth, or if women who consume cannabis are less likely to develop endometriosis, as indicated by many of the studies conducted up until now.

Many studies indicate that women who suffer from endometriosis benefit from therapies with cannabinoids or from consuming cannabis. (©Steven Schwartz)
Many studies indicate that women who suffer from endometriosis benefit from therapies with cannabinoids or from consuming cannabis. (©Steven Schwartz)

As we explained before, it is currently very complicated to diagnose this disease, which is why a simple biomarker (biological marker) of endometriosis, such as a reduced level of endocannabinoids in the blood or in the endometrial tissue, could save millions for health systems around the world, and years of unnecessary pain for the 176 million women who suffer from this disease.

Comment Section

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Paisley Love

Very well written article,thankyou so much.

21/04/2015

leonardo

interesante el articulo

21/04/2015

Dr. Vikram Chauhan

The ailment where the endometrial tissue is found on the outer part of the uterus or womb is termed as endometriosis. This stays between the lower part of the stomach or abdomen and the pelvic area. This disease does not spread on other parts of the body. This disease mainly occurs in the endometrial tissue that is accountable for lining the walls of womb. It is completely a feminine disease and has very mild indications. It is observed only when the symptoms get severe or painful. The causes of this disease include surgical implantation and weak immune organization of the body

02/05/2015

Elena Maria

First off you claim "It is completely a feminine disease and has very mild indications. It is observed only when the symptoms get severe or painful" - from what I understand Indication in medical terms means: a condition which makes a particular treatment or procedure advisable. So "very mild" indication means it is advisable to not treat Endometriosis. I have no words...I am left speechless. That is such awful and dangerous advice. Its actually quite sad.
You also claim: "This stays between the lower part of the stomach or abdomen and the pelvic area. This disease does not spread on other parts of the body." Why do I, and so many others have Endometriosis on our lungs, and if you're saying it's completely Feminine, you are intimating it's only seen on Female organs. Strangely so many women with Endometriosis have the disease infiltrating their bowel, intestines, bladder, etc. I think men have those organs as well?
Further you claim: "The causes of this disease include surgical implantation and weak immune organization of the body." So you have discovered the cause of Endometriosis when science clearly says states the causes are unknown (they do give possibilities).
I take high offense to anyone, especially a Dr. misinforming people about a disease that already is for the most part unknown and has a horrible stigma attached to it. I will not have children, I missed 6 years of work due to pain and symptoms, I have pain every day. If you can say a disease that destroys about 35% of the women who have it's chance to have a family, a disease that is explained in the way it acts, the pain and the exhaustion as a "cancer that doesn't kill you", a disease that you need excision surgery for every few years as a bandaid or harsh hormones, a disease MANY cannot control even through life changes, ETC. - a disease which has "very mild indications", you sound like you don't know what you're talking about. I don't know what kind of Dr. you are, but if you said that to me, I would laugh at you, say some choice words and leave the room. Thank you for being another medical "expert" to misinform the public on a very difficult and excruciating disease - a disease that is on many top 10 lists of most painful diseases.
Whoever reads this suffering from Endometriosis, please do not listen to Dr.'s like this - they will undermine the disease because they truly do not understand it. Find a Dr. that does.

14/02/2016

Kim

Your wring. It does spread. I have it everywhere. Not only do I need a hysterectomy, I also need a bowel reconstruction due to my endometriosis

08/03/2016

Rebecca

"This disease does not spread to other parts of the body". With all due respect this statement is incorrect. endometriosis implants have been found on the diaphragm, lungs and even on the brain. It is documented to have been found in the knee of a MAN!
You're assertion that one of the causes is surgical implantation is interesting I would like for you to expand on this.
There is growing evidence to show that immune regulation plays a part but whether it's the cause is not yet known.

21/03/2016

Tara

If you actually did research you would know that endometriosis has been found in the brain, lungs, and eyes, in women with rare severe cases of endometriosis.

13/04/2016

amy

I have abdominal wall endometriosis, which was caused from my C-section
it is in my c-section and six pack muscles. very painful and had to have surgery and mesh replacement to replace missing muscles. doctors need to be aware of spreading this during c-section surgeries. and they need to learn to treat iatrogenic (doctor made) endometriosis,

16/07/2016

N. Gressine.

" Very mild indications..." "Stays between the lower part of the stomach..." Endometriosis being an entirely feminine condition does not make it an insignificant one. It can and is often a debilitating condition for those who have to live with it. Its implications affect not only the sufferer, but her family as a whole. Think infertility, depression, chronic pain,repeated surgeries for intestinal obstruction secondary to adhesions. The implants can be found way beyond the boundaries of the"stomach", as they can be the cause of pleuritic chest pain from pleural space implants, hemoptysis, even headaches and seizures if implants are on the brain, meninges or in the ventricles. Please inform yourself before minimizing other people's burden. This shows a certain lack of empathy.

02/01/2017

Cory

What kind of doctor are you Vikram do you have any specific areas of study where did you get your information from ?

29/01/2017

Alison Hunter

I agree with Elena Maria. Please find a doctor that is knowledgeable in endometriosis. Do not let a doctor tell you that something is not wrong with your body when you know it is not right. Perseverance is often required in these situations. Also, it has been documented in autopsies that endometrial tissue had been doing in the lungs & even brain tissue of women (I believe this is documented in Women's Body Women's Health, a very inclusive women's health book by Christina N??????). Remember, it is called "practising" medicine. Be your own health care advocate.

04/02/2017

Dee

You sir are clearly an uneducated idiot and I pity your patients!

14/07/2017

Tara

I know for a fact that the endometriosis does spread and attach to other parts of the body, ive had it on bowels, uterus, liver, ovaries, old scar tissue. And yes some women do expierence more milder symptoms, but most have sever pain, and deal with constant side effects do to the disease and medications, and not to mention some women can not have children or have complications at birth, with not being able to carry to term. Im not sure what kind of doctor you are, but i hope not one for womens health. I suggest you do some more research!!

31/07/2017

Akay

no way dude. This disease is similar to cancer and can spread. I'm not even a doctor bt I can tell you that it can spread to the brain. My wife has stage 4 endometriosis and she's been taking pain killers for as long as I know her. I am so afraid of all the pills she takes because of all the toxins it might build up in her body. I am now doing research on cannabis oils and how effective it could be for her disease. If anyone can please shed more light around the cannabis treatment. I am from South Africa.

Thank you

11/09/2017

Survivor

I am living proof that endometriosis reaches other organs. I am scarred on my entire intestines all the way down to my anus. My left ovary was removed with my tube. She knew she needed to remove the rest but she didn't because she wanted to help me conceive. As a woman suffering from endometriosis I wish my state would allow medical marijuana so I can try it. Doctors should be taught fully about endometriosis. It has been around long enough there is No excuse. Women should be educated about it as well. It is a life threatening painful dangerous disease and it should be treated seriously. If I didn't go for my first ultrasound for my pregnancy which I lost along with every pregnancy I lost I would probably be dead because I was bleeding internally from my ovary. When u go to the hospital for this they treat u like your overreacting about the pain and send u home. So, I'm not surprised to read more about how medically educated people have no real idea about this disease or why they want to assume that they just might not really know what they are talking about. This article and many others should be brought to every doctors attention and taught in schools everywhere.

01/10/2017

Amanda

I had excision surgery with a specialist widely known in the endometriosis community. He found endometrial tissue embedded in my hip, thus why I experienced excruciating pain twice month. Your ignorance as a doctor is shocking.

04/11/2017

Little Star

Doctor? Doctor of what? Quackery? There was a famous case where a MAN in Japan being treated for prostate cancer developed endometriosis. This has happened in SEVERAL men and there is readily available peer-reviewed medical articles on this. If you ARE a doctor, you have no excuse for your ignorance and should be ashamed. I bet you think Sampson's theory of re-flux menstruation is true, as well, or that uteri wander inside of women and make them irrational.

24/03/2018

Angela

Mr. Vikram (I won't call you a doctor) are seriously mistaken and you sound like a quack.

08/04/2019

Marcia

Very interesting...I have this disease, took birth control for awhile, but stopped being effective...wished I could legally take a natural treatment for the severe pain and swelling I experience!

02/05/2015

Mickey

Hope others may find hope from the link below.

https://endometriosisanaturalcure.wordpress.com/2014/10/18/the-silent-female-epidemic-endometriosis-my-story/

22/06/2015

Viktoria

This was very helpful:) Thank you for sharing!

06/02/2017

N. D.

Very informative, one of the most inciting articles I have read on this topic. Thank you!

24/08/2016

Marcia

I was diagnosed with this disease and I was told my whole body was riddled with the cysts associated with endometriosis! I suffer with a great deal of pain and problems and would like more information about it. I was originally put on birth control to help alleviate some of the pain, but was cut off when insurance didn't want to cover birth control for a 52 year old woman! Plus it was causing other issues for me being on the pill. Also I was told that they would "disappear" after menopause, don't know if I believe that, but I refuse to have surgery, for one the cysts are EVERYWHERE throughout my body and surgery could not possibly remove it all, plus I don't want any doctors "practicing" on me! What are the alternatives? Pain killers do nothing for the pain and I hate taking them because of the other side effects they cause, but I can't bear the pain most days either! I am sick of "experts" that can't get their facts straight or even have a clue about what they are talking about! I don't want to break the law for relief but feel the issue really falls on deaf ears, nobody wants to hear about it or cares that I am suffering every day with such pain! What can I do?? I am desperate!

31/08/2016

Virginia

Hello Marcia,

I have endometriosis cysts in both ovaries, and, long to tell... but I am not on birth control pills, and I will not have any surgery (so far). I was in pain almost every month with my menstruation but acupuntcture help me a lot with that; althought it seems to do not work for shrinking the cysts, it is beneficial to reduce inflamation and pain.

What it was very stressfull for me is that the cyst bothered me during my sex relationships. It did not hurt, but it was quite unconfortable. I also use to have unconfortable feelings in my left side, where I have the biggest endometrioma.

In my life I have smoked marihuana... But not all the marihuana strains have the same beneficts. Anyway, during my last holidays my friends gave me to smoke a very good one marihuana that was magic to me... Inflamation dissappeared and I did not felt any disconfort, it was like the cyst dissapeared (although I know it is still there). Due to this experience, I am starting having Organic CBD Oil, it is an oil which is stracted from the marihuana, and it is said it has medical beneficts. It is legal, because there are no high THC concentrations in such oil and you reduces the side effects of smoking... Look for information and give it a try. My firts bottle arrived today, so I can not tell if it works on me or not ...

12/09/2016

Evil Emoji

well... If it could just get damn legalized, then me and my mom wouldn't be suffering much longer, ive tried soo many ways to get rid of the pain of my period and tried to stop it by starving myself, but it will not work, then the day came when I did it. I felt better then I have ever before! I could focus in school the day after and was not in the nurse's office or had to take pain killer! Now I cannot do anything in school and the bleeding keeps going and keeps going! I'm only 13 and need to go see a doctor for a never ending period! I get a break but when I do I'm so pail I can see half of my veins! and tomorrow I have a mile test and I am gonna die

IT'S NEVER ENOUGH!

27/10/2016

Kay

So, I'm still confused. Is CBD good or bad for those with Endometriosis?

07/05/2017

Melissa

Kay,
In my personal experience, I began using a pure CBD vape pen and have felt a miraculous improvement. I wish I had tried it sooner!! I suffer from chronic back pain among many other endometriosis symptoms, and the day I began using the CBD, I actually shed some tears because I hadn't felt "normal" or pain free in SO LONG. My mood improved so much, I actually felt like myself again! The CBD when inhaled in this vape form worked almost instantly.

If you use any vape cartridges you must make sure it's only 100% CBD oil and NOT mixed with anything else. Some brands are mixed with MCT oil (basically coconut oil, which shouldn't be inhaled!!), propelyne glycol, glycerine, etc.)

I hope this helped you!

21/06/2017

Grant

I am beginning to think that as with Cancer, Endometriosis could be cured with extreme concentrations of CBD or a THC/CBD mix? There are quite a few examples of people going into remission through taking a product called Phoenix Tears, or better known as Honey Oil, in large concentrations at once. The procedure is not cheap, though not as expensive as a Chemo treatment. For instance, you would require 60 grams in 90 days for Cancer, and the average cost ranges in the $40-$70 range per gram, vs $14,000 for one month's worth of Chemo. If you transfer this approach to Endo, you might have a great deal of relief, if not a movement towards remission of these symptoms?

One thing to point out; When it comes to taking CBD or Cannabis, the only time you will encounter the healing aspects of the plant, vs a short state of ease, is through ingestion. You can smoke until you are blue in the face, and you will not experience the true healing powers of this plant. Once you start to ingest it, you will then be introduced to its true purpose. I would love to see a trial conducted on a group of women where they took Suppositories vaginally of the concentrated Cannabis to facilitate movement towards finding a cure for this? This is a miraculous plant, that has been stripped from us for almost a century due to dubious means. With the resurgence of this product, I would really like to see more "out of the box" attempts regarding ailments such as this.

On a side note, my niece and a friend suffer from this, and we are experimenting with different applications of CBD and Cannabis to facilitate a potential fix for them. They are both young women, and they as well as all others deserve a quality of life.

03/06/2017

Martina

Hi I have started to take the 10mg cbd oil 3 days ago started off with 3 drops no relief not at 7 drops still in so much pain with this endometriosis does it take long to get into the system I've heard really good things about the oil I'm on a serious amount of medication and would love nothing better to get off them thanks again

23/09/2017

Scarlet Palmer

Dear Martina,

Thank you for your comment. We are sorry to hear about your situation. Unfortunately, as Sensi Seeds is not a medical practice, we are not able to provide any advice relating to medical situations other than to consult your doctor or other licensed medical professional. This article, written specifically for healthcare providers who may not be aware of the many properties of cannabis, may be useful to you in talking with your doctor. You could also try to contact local medicinal cannabis support groups, if you have not already done so. In the UK, there is the United Patients Alliance (you can find them on Facebook) and in the US and EU there are many branches of NORML (google NORML followed by your area name). We hope this is helpful.

With best wishes,

Scarlet

25/09/2017

Amanda Lawrence

This article is so well written and educational. As an Stage 4 Endometriosis fighter, I have been thru several major surgeries, including a total hysterectomy. To alleviate pain, I made this decision to undergo a fourth surgery because I had Endo glued to all my reproductive, disgestive, and urinary organs. My surgery left my right arm with severe nerve damage due to laying how I had to lay for 8 hours during surgery. All to alleviate pain. I have been prescribed every treatment possible. Hormone therapy, Lupron cycles, etc...

Point of my story is this. I have been fighting this disease for over 15 years. 10 of which I had an actual diagnosis from a laprascopic procedure turned badly into a laparatomy when they realized the extent of the damage that had already been done by the sticky lesions and 30 day cycles. BLAH.

I WISH THERE WAS A WAY TO PROVIDE THIS RELIEF AND TREATMENT LEGALLY TO WOMEN WHO SUFFER SILENTLY WITH AN INVISIBLE DISEASE.

It hides and grows. The only thing you can do to survive is minimize the growth, the inflammation, the depression from medical expenses and loss of way of life.

Much love to the author of this article and it's intelligent and educated analysis of this treatment.

04/10/2017

Heather

Great article. I was diagnosed after I had a tubal ligation at 26. My mother had a hysterectomy and they left one ovary in her. She died of ovarian cancer at 54 yrs old. I noticed almost right away the positive effects cannabis had on managing pain. All other treatment options were either barbaric or came with too many side effects, and unfortunately I’m allergic to ibuprofen and nsaids. My pain comes with ovulation and I can go from pale, sweating and in so much pain I can barely breathe (let alone move) to sore but fine in ten minutes.

27/12/2017

Carol

I have an endometrioma on my right ovary. I've know about since 2016, after my endocrinologist found one on my left side which was about 1cm and the one on my right was almost 3cm. (Within a few weeks my left one burst, I felt no pain and since then it hasn't come back).
We tried to find a treatment plan so she decided to put me on spironolactone at first because I have a family history of high blood pressure and strokes. (My grandpa had 5 strokes before he passed away and my mum has had 2 micro strokes. She now takes beta blockers and blood thinners everyday now).
I had started using the spironolactone, I was about 3 months in when the endometrioma on my right side started rupturing, a few months after it was discovered.
I was 26 at the time and had never experienced any sort of pain like that in my life!
My periods were very casual. No migraines. No cramps. No major bloating. No PMS. No back pain.... ZERO! Aunt flow would come, and just like that she was gone. So, when I felt this endometrioma rupture for the first time I literally thought I was in hell. I couldn't sleep all night from sharp pains. I had a fever and chills, my back hurt so bad there was no position in which I could sit or lie down. I began to throw up, violently. I was in so much pain I could barely communicate with anyone.
Anyways, after being rushed to the hospital and having a bunch of tests performed, (blood tests, CT scans, ultrasounds, pelvic exams) and a lot of drugs were administered I was able to go home. Needless to say I missed a lot of work from not being able to move around without pain for a few days.
Fast forward... I happened once more... and then again. Every time it happened I was baffled. I could not believe this was my life now! I thought to myself... am I going to have to spend my nights at emergency once every month? How could this have happened? I went from never feeling a thing.... to the most excruciating pain I have ever felt! It was unbelievable.
Well, at that point I was already seeing a bunch of specialists: a gynocologist, an endocrinologist, a dermatologist, a haematologist and a neurologist.
To which they all came to the conclusion that it was time to put me on birth control. They were all hesitant at first because of my family history. I was a smoker as well before hand. Many factors...
I had always been a person who did not like to rely on medicine very much, I would rarely ever have to need to take anything. However, the pain I was enduring and the symptoms I was being left with from all the hormonal imbalances, the amount of work I was missing made me panic and so I said okay to trying the birth control.
Over time there was a bunch of trial and error until I found the right one I felt comfortable taking that didn't make me feel depressed, anger, crazy or that didn't make my skin react or make my hair fall out.
It's been about a year and a half of no ruptures. The endometrioma is the same size, 3 cm. Once in a while I can feel it twisting, I'll feel some mad pokes on my lower side, but it goes away.
My only problem now is the side effects I have with the pill I'm on. I get some serious bouts of nausea and some very unforgiving migraines.. sometimes they're quick. Sometimes they last for days. And yes, I could never compared these annoyances to rupturing cysts, I am grateful we found a temporary solution. But I have heard that the CBD oil has the ability to shrink down lesions and help with auto immune issues, inflammation and so on, all very much associated with endometriosis, PCOS, and fibroids.
My fear really is me ending up in the hospital with a rupture again. I really do not like being on hormones, you always here about all the way it can affect your health. It's truly scary.

Finally, my question is how can I transition to using CBD oil? I'm curious if I could take them together or if I go cold turkey and stopped the Birth Control and only use the CBD oil how long before I could see some positive effects? I've heard of women treating themselves with CBD oils, do they have to take any other vitamins to go along with it?
Does anyone have a successful transitioning story from birth control to CBD oils?

14/03/2018

Robin

I am intrigued with the Cannnabis possibility of helping relieve pain, inflammation, etc. I was diagnosed over 17yrs ago, had a partial hysterectomy and my Dr. hoped it would give me 10years before it was back. Well, 17years later it is here with a vengeance at times as I lie on the couch in pain, have little to no energy and am overly tired. My normal chipper self is lacking. I was re-diagnosed a month ago and best option is surgery once again..... However, I would prefer to avoid it if at all possible and have been researching and changing lifestyle a little more than I had already in hopes to do this naturally with eating habits, exercise & supplements (vitamins, minerals and oils I am lacking) per my research. I have really implemented this once verified I wasn't losing my mind this past year with symptoms and I haven't had a period for over 17yrs so hard to know if associated with that time of the month or not but I do have both ovaries. My left ovary looked good but my right has a very visible 4cm mass and likely more in and around the normal areas. Pain sometimes comes and goes but can usually feel it if I position myself incorrectly, sex hurts (very hard for me as I don't say much to my husband of 24yrs as I don't want him to feel bad and just try to reposition myself)…. pain has increased and sometimes makes normal day to day hard as it's in my low back, front ovary area as well as hurts and aches more often than not inside my right vaginal area (sorry to be so descriptive). Does anyone know if you can just use the Oil topically? Will it help as I know it has helped some of my friends from other ailments from arthritis to broken ankle hurting when walk too much to do the damage but when using the oil/lotion can walk miles and swelling stays down. I am NOT a smoker, I am a lightweight the couple of times I have tried it and would feel better doing it topical if I can find out if it has helped others this way before wasting my money..... Please, if you have tried it or no someone whom has please let me know as I want my normal quality of life back, hubby has been on the road luckily everytime I have a really bad few days so he doesn't know how bad it really is affecting me.

21/05/2018

Scarlet Palmer

Hi Robin,

Thank you for your comment. I'm really sorry to hear about your situation. Don't apologise for giving details - there is no shame in what you are going through and we're all adults here. I'm obliged to give you the answer below, but hopefully someone with direct experience can let you know if it worked for them. My personal opinion is that using oil topically would offer some relief; I have not tried it vaginally but I have tried rectal suppositories and they definitely had an effect. You can read my report on that experience here. If you read the comments on that article you will see that suppositories have been used with success by other people too.

You may also wish to investigate a product called 'Foria Relief', a pessary formulated to give relief from menstrual pain. Another option could be the products from 'Whoopi and Maya' which are developed for the same reason. Although what you’re suffering is much worse than menstrual pain, these products might alleviate it slightly.

As Sensi Seeds is not a medical agency or practitioner, we cannot give any kind of medical advice other than to consult our registered healthcare professional. This article about the potential benefits of medicinal cannabis might be useful for you to show your healthcare provider if they are not familiar with it.

You may also find it helpful to contact a support group for medicinal cannabis patients. In the UK there is the United Patients Alliance, and throughout much of the rest of the world there is NORML, who should be able to put you in touch with a group in your area (search United Patients Alliance or NORML followed by your area name).

These are our pages on medicinal cannabis and medicinal cannabis strains, which you might also find interesting.

With best wishes,

Scarlet

25/05/2018

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